Medical Case Reports

contact@imedpub.com Submit a Manuscript

Polymyxins

Polymyxins area unit well-established antibiotics that have recently regained vital interest as a consequence of the increasing incidence of infections because of multidrug-resistant gram-negative microorganism. Colistin and antibiotic drug B area unit being seriously reconsidered as last-resort antibiotics in several areas wherever multidrug resistance is determined in clinical medication. In parallel, the significant use of polymyxins in medical specialty is presently being reconsidered because of exaggerated reports of polymyxin-resistant microorganism. status testing is difficult with polymyxins, and presently on the market techniques area unit bestowed here. makeup and phenotypical strategies that offer relevant data for diagnostic laboratories area unit bestowed. This review conjointly presents recent works in respect to recently known mechanisms of antibiotic drug resistance, together with chromosomally encoded resistance traits likewise because the recently known plasmid-encoded antibiotic drug resistance determinant MCR-1. medical specialty options summarizing this data therein field area unit bestowed The target of polymyxins is that the outer membrane of gram-negative microorganism. attributable to Associate in Nursing electricity interaction occurring between the α,γ-diaminobutyric acid (Dab) residue of the charged antibiotic drug on one aspect and also the phosphate teams of the charged lipoid A membrane on the opposite aspect, power cations (Ca2+ and Mg2+) area unit displaced from the charged phosphate teams of membrane lipids (12). The lipopolysaccharide (LPS) is thus destabilized, consequently increasing the porousness of the microorganism membrane, resulting in run of the living substance content and ultimately inflicting necrobiosis

High Impact List of Articles
Conference Proceedings

Relevant Topics in Medical Sciences

Awards Nomination 17+ Million Readerbase
Google Scholar citation report
Citations : 230

Medical Case Reports received 230 citations as per Google Scholar report

image
Medical Case Reports peer review process verified at publons
image
Abstracted/Indexed in
  • Google Scholar
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Publons
  • Secret Search Engine Labs
  • Euro Pub

View More »

Open Access Journals