Cancer Biology and Therapeutic Oncology

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Malignant Gliomas

The malignant gliomas are primary brain tumors and represents about 78% of all malignant tumors of the central nervous system. The majority of these tumors are considered as high-grade tumors according to the current classification of the World Health Organization (grades III and IV) when diagnosed. Glioblastoma (GB) is the most aggressive form of gliomas, and is highly infiltrative and is morphologically very heterogeneous. Currently, the protocol adopted for the treatment of glioblastoma is based on surgery followed by radiation therapy and chemotherapy. Gliomas can occur in the brain and in various locations in the nervous system, including the brain stem and spinal column. Glioblastoma cells have more genetic abnormalities than the cells of other types of astrocytoma brain cancer. As a result, researchers believe that several different genetic mutations are involved in the development of these cancers. These genetic mutations can be caused by: Inherited DNA defects.

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Citations : 42

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