International Journal for Case Reports

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Hypersensitivity Syndrome

DIHS is a dangerous autoimmune reaction thought to be regulated by T cells and includes a variety of cytokines, inflammatory cells, and regulatory mechanisms, although not directly understood. This machine is characterized as using the immune system through its causative agents or metabolites rather than having a direct toxic effect on keratinocytes.

A study by Bellon et al. supported the T-cell-mediated hypothesis by identifying 85 species that were differentially expressed during the acute phase of DIHS. Most of the genes included in the acute phase were encoding proteins involved in cell cycle, apoptosis, and cell initiation activities; Nine were involved in the immune response and inflammation. Bellon et al. and I found that the levels of histone messenger RNA were statistically significantly increased in large and moderate mutations. The genes that were strongly upregulated in syndromes with cutaneous and mucosal involvement are those that involve inflammation, now called alarms or damage-related molecular patterns.

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