Haematopoiesis

Haematopoiesis refers to the commitment and differentiation processes that lead to the formation of all blood cells from haematopoietic stem cells. In adults, haematopoiesis occurs mainly in the bone marrow (medullary), but it can also occur in other tissues such as the liver, thymus and spleen (extramedullary).

Blood is an essential transport medium for the human body, which facilitates movement of erythrocytes, leucocytes and platelets.

Blood is composed of haematocrit and plasma (approx. 45% and 55% respectively). 

Haematocrit is composed of erythrocytes and it is the densest component of blood. In contrast, plasma is mainly composed of water - though it also contains protein (e.g. albumin, immunoglobulins, fibrinogen) and non-protein components (e.g. vitamins, lipids, hormones).

When left stand within a test tube blood will separate out into its different layers. The more dense haematocrit will aggregate at the bottom, whilst plasma will float on the top. A thin layer, termed the 'buffy coat', sits in-between. It contains leucocytes and platelets. It accounts for <1% of blood volum

 

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