A bioreceptor is a biological material (e.g., an enzyme, antibody) that is sensitive to the analyte (e.g., enzyme substrate, DNA complement, antigen). It is important for the bioreceptor to directly target the target analysis to prevent interference from other sources of signals or substances from the sample surface. The unity of the biosensor is that the two components are combined into one single sensor. The biosensor has two components: the bioreceptor and the trans-ducer. A bioreceptor is a biomolecule that detects the target analyzer even though the transducer changes over the date of admission into a sound signal. Clark and Lyons were the first to introduce the enzyme-based biosensor in 1962. They infused a biosensor to detect blood sugar in blood plasma, based on the enzyme glucose oxidase in the electrochemical sense. The process of analyzing the analyst involves a number of possible mechanisms: an enzyme that converts the analyst into a tangible product; enzyme uptake is inhibited or activated by the analyst; as well as observing changes in enzyme structures.