Metabolites are the intermediates and products of metabolism, Metabolites can be categorized into both primary and secondary metabolites, Primary metabolites are considered essential to microorganisms for proper growth. Secondary metabolites do not play a role in development, growth, and reproduction, and are formed during the stationary phase of growth, metabolites are the small molecular weight compounds produced by microbes, to regulate other organisms beneficial to them and suppress organisms that are harmful and also develop their own growth and development.