Synthesis, quality control and biodistribution of techneium-99m triamcinolone acetonide (99mTc- TA) complex: an inflammation tracer agent

Faheem Askari Rizvi; Syed Ali R Naqvi; Samina Roohi

doi:10.21767/2574-285X-C1-003

Synthesis, quality control and biodistribution of techneium-99m triamcinolone acetonide (99mTc- TA) complex: an inflammation tracer agent

International Conference on Nuclear Medicine & Radiation Therapy
October 01- 02 , 2018 Stockholm , Sweden

Faheem Askari Rizvi, Syed Ali R Naqvi and Samina Roohi

Government College University Faisalabad, Pakistan Pakistan Institute of Nuclear Science and Technology, Pakistan

Posters & Accepted Abstracts: J. med phys & appl sci 2018

DOI: 10.21767/2574-285X-C1-003

Abstract

In the present study, synthesis of 99mTc-triamcinolone acetonide (99mTc-TA) complex and its stability using set of quality control parameters such as ligand concentration, reducing agent concentration, pH, temperature and reaction time was assessed. 99mTc- TA complex was characterized in terms of percent (%) yield, stability in saline and serum using chromatographic procedures. Radiochemically, the 99mTc-TA complex was found quite stable in saline and serum. After 30 min of reaction, the complex showed maximum radiochemical yield of 96.32% which decreased to 96.25% after 4 h of incubation period. In serum, the % yield of radiochemical was remained same up to 2 h which decreased to 93.5% at 24 h time point. Normal biodistribution pattern in Sprague Dawley rats revealed liver, stomach and kidneys as areas of high 99mTc-TA complex uptake (8.44±1.32%, 8.75±1.03% and 12.67±1.21%, respectively) at 1 h post injection time point. Scintigraphy of 99mTc-TA in rabbits showed similar eco as observed in biodistribution study. Based on the promising results obtained in context of in vitro and in vivo stability and biodistribution, 99mTc-TA complex could be further studied to identify the inflammation based diseases.