Synthesis, labelling and preliminary bioevaluation of 99mTc-urea as a potential kidneys imaging agent

M H Sanad; Dina H Salama

doi:10.21767/2574-285X-C1-003

Synthesis, labelling and preliminary bioevaluation of 99mTc-urea as a potential kidneys imaging agent

International Conference on Nuclear Medicine & Radiation Therapy
October 01- 02 , 2018 Stockholm , Sweden

M H Sanad and Dina H Salama

Egyptian Atomic Energy Authority (EAEA)-HLWMC, Egypt National Center for Radiation Research and Technology-AEA, Egypt

Posters & Accepted Abstracts: J. med phys & appl sci 2018

DOI: 10.21767/2574-285X-C1-003

Abstract

We present the development and characterization of a [99mTc] tricarbonyl urea. Labelling with high yield and radiochemical purity was achieved through the formation of a [99mTc] tricarbonyl urea radiotracer. The radiolabeled compound was stable and exhibited plasma protein binding (approximately 40%). The logarithm of the partition coefficient (log p) value of [99mTc] tricarbonyl urea was -2.55±0.17 (hydrophilic). Bio-distribution studies in normal mice confirmed the suitability of [99mTc] tricarbonyl urea as a novel tracer to image kidneys. [99mTc] tricarbonyl urea could be considered a new selective radiotracer for kidneys imaging