American Journal of Pharmacology and Pharmacotherapeutics

Solubilization of drugs using sodium lauryl sulfate: experimental data and modelling

European Congress on Pharma
August 13-14, 2018 Paris,France

Ali Shayanfar, Mohammad Norouz Alizadeh and Abolghasem Jouyban

Tabriz University of Medical Science, Tabriz, Iran

Posters & Accepted Abstracts: J Pharmacol Pharmacother

DOI: 10.21767/2393-8862-C1-003

Abstract

Micellar solubilisation is a great method for increasing drugs solubility in aqueous environments. At concentrations above the critical micelle concentration (CMC), micelles are formed and they are able to increase the apparent aqueous solubility of poorly soluble drugs. Sodium lauryl sulfate (SLS) is one of the common solubilizing agents in pharmaceutical sciences. Investigation on the water solubility of drugs in the presence of surfactants and the development of a relationship between drug solubility in the presence of SLS and structural descriptors is an important issue in the prediction and understanding of the solubilisation mechanism. The aims of this study are: determination of experimental solubility of drugs in the presence of SLS and development of models for finding a relationship between solubilisation factor by SLS and structural descriptors. Samples were prepared by adding excess amount of 19 drugs (with diverse structural and physicochemical properties) to water and an aqueous solution of SLS at different concentrations, that is, less than (0.1%) and above the CMC (0.5%). The mixtures were placed in a shaker-incubator for 72-96 h at 37°C. Then, the equilibrated samples were filtered and analyzed at maximum wavelengths by UV-spectrophotometry and the concentrations were calculated based on the calibration curves. Afterward, the molecular descriptors of drugs were computed and their relationship with solubilization factor in the presence of SLS was investigated. Most of the drugs showed a considerable increase in solubility above the CMC (0.5%) of SLS. Therefore, the effective mechanism for solubilization by surfactants is the formation of micelles. On the other hand, a good correlation was observed between structural descriptors and solubilization power in the presence of surfactant. Overall, SLS is a good solubilization agent and the solubility in aqueous solution of SLS depends on various structural descriptors.

Biography

Ali Shayanfar obtained his Pharma D in 2009 and PhD in Pharmaceutical Chemistry in 2013 from Tabriz University of Medical Sciences. Currently, he is an Assistant Professor of Pharmaceutical Chemistry at Tabriz University of Medical Sciences and has published more than 70 research articles in international journals. He has received gold medals from the Iranian Razi Research Festival in 2013 for his academic achievements.

E-mail: shayanfara@outlook.com