Journal of Organic & Inorganic Chemistry

Phytochemical and antimicrobial activity of bioactive compound extracted from Embelia schimperi Vatke against human pathogens

Annual Congress on Medicinal Chemistry, Pharmacology and toxicology
July 30 - 31 , 2018 Amsterdam , Netherlands

Tesfaye Wolde, Tamru Demsis, Shemsu Ligani and Tesfaye Hailemariam

Wolkite University, Wolkite, Ethiopia

Posters & Accepted Abstracts: J Org Inorg Chem

DOI: 10.21767/2472-1123-C3-009

Abstract

Background: Embelia schimperi is among medicinal Mvrsinaceae plants found in Ethiopia which find a wide range of application in ethno-pharmacology as antimicrobials and antihelmentic. It has been used for the treatment of intestinal parasites especially tapeworm infestations for centuries in Ethiopia. This study has therefore evaluated the efficacy and phytochemical analysis of E. schimperi thereby generating relevant preclinical information. Methods: The fruit berries of E. schimperi were extracted with cold methanol, n-hexane, ethanol, petroleum ether. The antihelmentic activity was evaluated on the earthworm Pheretima posthuma collected due to its anatomical and physiological resemblance with the intestinal round worm parasites of human. Antibacterial activity was carried out with the pure compounds against Staphylococcus aureus and Salmonella typhi. Results: The paralysis causing concentration within 30 minutes of the crude extracts and Albendazole were 50 mg/ml and 25 mg/ ml respectively. The crude extracts showed nematicidal activity against the earth worms whereas the nematocidal concentration required within 30 minute for the crude extracts and Albendazole were 100 mg/ml and 25 mg/ml. The crude extracts showed nearly similar activities against all the tested bacteria in the study. From zone inhibition diameters of compounds Embelia schimperi methanol and ethanol extract were compared on S typhi and S. aureus, both compounds were showed activity on S. aureus nearly in similar way. These compounds were reasonably active against S typhi and S. aureus it makes an appropriate candidate for further investigation in control of these multi-drug resistant bacteria. Conclusion: Antibacterial activities vary with the test organisms, plant material and the solvents used. Thus, the result ascertains the value of plant used in the study could be of considerable interest to the development of new antimicrobial drugs.