Journal of Organic & Inorganic Chemistry

New aspects of synthesis and microbiological applications of β-EWG functionalized β-nitrostyrene

Annual Congress on Medicinal Chemistry, Pharmacology and toxicology
July 30 - 31 , 2018 Amsterdam , Netherlands

Oleg M Demchuk, Anna Boguszewska-Czubara, Karolina Kula, Artur Wnorowski, Anna Biernasiuk, Lukasz Popiolek, Dawid Miodowski and Radomir Jasinski

Maria Curie-SkÃ?Â?odowska University, Lublin, Poland Medical University of Lublin, Lublin, Poland Cracow University of Technology, Cracow, Poland

Posters & Accepted Abstracts: J Org Inorg Chem

DOI: 10.21767/2472-1123-C3-009

Abstract

Conjugated nitroalkenes are valuable precursors in organic synthesis they have significant affinity to nucleophilic reagents as diazocompounds, nitrones, ylides, carbodienes, vinyl ethers etc., additionally; nitro group may be easily converted to many other functional groups. Subsequently it was known, that nitro group conjugated with sp2 carbon atom stimulate many forms of biological activity. Considering these facts we decided to check a series of (E)-2-aryl-1-cyano-1-nitroethenes as potential antibacterial and antifungal agents but without genotoxic properties. A homogenous series of β-EWG functionalyzed β-nitrostyrenes were synthesized and characterized by IR, UV, 1H-NMR and 13C-NMR spectra. Obtained compounds were screened in vitro against a panel of reference strains of bacteria and fungi and their cytotoxicity towards cultured human HepG2 and HaCaT cells was established. Antimicrobial results indicated that four of synthesized compounds exhibited significant antimicrobial activity against all tested reference bacteria and fungi belonging to yeasts with a specific and strong activity towards B. subtilis ATCC 6633. The details of our studies, which describe the synthesis, activity, and proposition for the mechanism of an action of studied compounds, will be presented