Microstructural changes revealed by diffusion tensor imaging (DTI) in Alzheimers disease

Navid Sarmast Alizadeh; Javad Sheikhi; Kayvan Mahdavi
Khazaei; Bahram Moazaami; Mohammad Reza Hoseinshahi

doi:10.21767/2471-8548-C1-003

Microstructural changes revealed by diffusion tensor imaging (DTI) in Alzheimers disease

13^th World congress on Alzheimers and Dementia
December 06-07, 2018 Amsterdam, Netherlands

Navid Sarmast Alizadeh,Javad Sheikhi, Kayvan Mahdavi Khazaei, Bahram Moazaami, Mohammad Reza Hoseinshahi

MRI Physicist ,High-Tech Department Pars Hospital- Department of Imaging ,Imam Khomeini University Hospital, Tehran University of Medical Science, Iran MRI Physicist ,Shahid Beheshti University Hospital High-Tech Department Pars Hospital ,Iran High-Tech Department Pars Hospital, Iran High-Tech Department Pars Hospital, Iran

Posters & Accepted Abstracts: J Neurol Neurosci

DOI: 10.21767/2471-8548-C1-003

Abstract

Background: Alzheimer's disease (AD) is a progressive and degenerative Process in gray (GM)) and White (WM) matter of the human brain. Recent studies have been focused on pre symptomatic microstructural changes that will assist the early diagnosis of AD. To date Magnetic resonance imaging (MRI) based microstructural changes research looked into neuronal destruction in gray matter whereas, there are fewer studies on white matter abnormality. Methods: Long term DTI data from the Alzheimer's disease Beginning in 2 database were used to test. (A): the within-group microstructural white matter changes in Samples with AD and healthy controls at baseline and The first six months ; and (B): the between-group microstructural changes differences in Samples with AD and healthy controls at both Time points. Results: (A): Within-group: longitudinal Tract-Based study disclose that Samples with AD and healthy controls both had decreased fractional anisotropy (FA) and increased mean diffusivity (MD) with changes in the hippocampal cingulum exclusive to the AD group.( B): Between-group: relative to healthy controls, Samples with AD had lower FA and higher MD in the hippocampal cingulum, as well as the corpus callosum, internal and external capsule; corona radiata; posterior thalamic radiation; superior and inferior longitudinal fasciculus; fronto-occipital fasciculus; cingulate gyri; fornix; uncinate fasciculus; and tapetum Conclusion: The results of current study highlight that sensitivity toward white matter microstructure is a promising target for AD microstructural changes research. Further longitudinal studies on both white and gray matters are recommended to get a deeper understanding of these microstructural processes.