Journal of Transmitted Diseases and Immunity

Induction of autoimmune antibodies and the immune response of prolactin direct the management in patients infected with hepatitis C virus: an Iraqi study

Joint Event on 22^nd Edition of International Conference on Immunology and Evolution of Infectious Diseases & 12^th Edition of International Conference on Tissue Engineering and Regenerative Medicine
May 10-11, 2018 Frankfurt, Germany

Hadaf Dhafir Al Yaseen

University of Baghdad, Iraq

ScientificTracks Abstracts: J Transm Dis Immun

DOI: 10.21767/2573-0320-C2-005

Abstract

Hepatitis C virus (HCV) is a serious infectious disease that can cause lifelong infection. Infection with chronic hepatitis C virus (HCV) can lead to autoimmune hepatitis (AIH) in a minority of patients. Viral infection induces, both (in vivo and in vitro) tumor necrosis factor (TNF-alpha) production in hepatocytes, and these findings suggest that TNF-alpha may have an important role in human liver diseases induced by viruses, together with the prolactin hormone, which is an endocrinal hormone that acts like a cytokine involved in immune response. Our study showed that chronic hepatitis C virus infection associated with a statistical significant increase in the antismooth muscle antibody, while no statistical significant increase in antinuclear antibody were shown in this study. The study elucidated a statistically non-significant increase in mean value of prolactin hormone in chronic hepatitis C patients but a significant increase in tumor necrosis factor-alpha. No significant correlations were found between prolactin hormone and tumor necrosis factor-alpha. The study concluded that chronic hepatitis C associated with an immunological abnormality mainly represented with antismooth muscle antibody. Tumor necrosis factor-alpha increased in chronic hepatitis C virus infection with no significant correlations with prolactin hormone.

Biography

Prof. Dr. Hadaf Dhafir Al Yaseen was faculty in University of Baghdad in the Department of Biochemistry, College of Medicine at University of Baghdad. She finished her Post Doctorate in Clinical Biochemistry at Al-Nahrain University. She is currently the head of the Department of Clinical Biochemistry, University of Baghdad, Iraq. She actively participated in 43 local conferences in Iraq and 26 abroad, making a total of 69 conferences attendance and paper presentation. She also published 85 articles. Email:hedefelyassin@gmail.com