Higher and lower levels of serum alanine aminotransferase within current range in the elderly are associated with all cause mortality

Hemda Schmilovitz Weiss; Rachel Gingold Belfer; Doron Boltin; Yichayaou Beloosesky; Joseph Meyerovitch; Ruth Tor; Nidal Issa; Alon Grossman; Nira Koren Morag; Avraham Weiss

doi:10.21767/2471-982X-C1-003

Higher and lower levels of serum alanine aminotransferase within current range in the elderly are associated with all cause mortality

Joint Event on 7^th Edition of International Conference on Internal Medicine and Patient Care & 6^th Edition of International Conference on Pain Management
March 26-28, 2018 Vienna, Austria

Hemda Schmilovitz Weiss, Rachel Gingold Belfer, Doron Boltin, Yichayaou Beloosesky, Joseph Meyerovitch, Ruth Tor, Nidal Issa, Alon Grossman, Nira Koren Morag and Avraham Weiss

Hasharon Hospital - RMC, Israel Beilinson Hospital â�?�? RMC, Israel

Posters & Accepted Abstracts: Int J Anesth Pain Med

DOI: 10.21767/2471-982X-C1-003

Abstract

Background: Serum alanine aminotransferase (ALT) levels below and above normal range has been found to serve as a marker of liver injury and to predict all-cause mortality. The need to adjust the normal range by age, gender, or other parameters remains unclear. The current normal range of serum ALT in Israel is 0-34 IU/L for women and 0-45 IU/L for men. Aim: We aimed to test the applicability of the current normalrange values of ALT in the elderly. Design: A retrospective design was used. The study population consisted of community-dwelling individuals aged â�?¥65 years who were tested for serum ALT in 2002 at a large health management organization and followed until end-December 2012. Methods: Data were collected on demographics, laboratory tests, co-morbidities, and mortality. Results: The population included 49,634 subjects (59% women, mean age 83.2�?±6.3 years). ALT levels in the range of 16-25 IU/L were associated with the lowest mortality (HR=1), and values of <16 IU/L and >25 IU/L (unadjusted) were associated with higher mortality risk, yielding a U-shaped pattern. Conclusions: Very low and very high levels of serum ALT within current normal range are associated with an increased risk of death in community-dwelling individuals â�?¥65 years old.