Journal of Clinical Cardiology and Research

Gut microbiota dependent Trimethylamine N-oxide biosynthesis, a universal metabolic pathway, contributes to cardiometabolic disease

International Conference on Heart and Cardiovascular Diseases
July 21, 2021 | WEBINAR

Zeneng Wang

Lerner Research Institute, USA

Keynote: J Clin Cardiol Res

Abstract

Gut microbes can metabolize nutrient with structural formula containing trimethylamine (TMA) moiety, such as, phosphatidylcholine, choline, carnitine and γ-butyrobetaine in diet, to produce TMA and TMA is further oxidized as trimethylamine N-oxide (TMAO) catalyzed by host hepatic Flavin monooxygenases (FMOs). The TMAO metaorganismal pathway is a universal metabolic pathway, contributing to cardiometabolic disease. TMAO shows multiple pro-atherogenic properties including activating NF-κB, MAPK signaling, NLRP3 inflammasome and PERK pathway, leading to atherosclerosis, thrombosis, heart hypertrophy, chronic kidney disease, fatty liver disease and obesity even gallstone formation. TMAO can independently predict future risk for major adverse cardiac events (non-fatal myocardial infarction, stroke and death). Targeting this metabolic pathway by limiting TMA precursor enriched diet consumption, administration of prebiotic or probiotic to decrease the bacterium abundance which encodes enzymes involved in the conversion of TMA precursors to TMA or inhibitors to TMA lyase and FMOs, can decrease circulating TMAO, therefore ameliorating cardiometabolic disease.

Biography

Zeneng Wang is working in Department of Cardiovascular and Metabolic Sciences, Lerner at Research Institute, Cleveland Clinic, Cleveland, Ohio, USA. He is also working as an Assistant Professor in Case Western Reserve University, USA