International Journal of Anesthesiology & Pain Medicine

Griseofulvin vs. terbinafine in the treatment of tinea capitis

Joint Event on 7^th Edition of International Conference on Internal Medicine and Patient Care & 6^th Edition of International Conference on Pain Management
March 26-28, 2018 Vienna, Austria

Nawal Hatem Herzallah,Humoud Mansour AlKhalaf, Adnan Meteb Mohamed Almezani, Youssef Mohammad Almodhaibri, Mustafa Mohamed Ali Almusallami, Jumanh Khalid Attiah, Abdulaziz Mohammed Alsahli, Maha Fahad Alluqmani, Fatimah Mohammed Saeedi

Royal College of Surgeons in Ireland, Ireland
Hail university, Saudi Arabia
Qassim University, Saudi Arabia
Hera General Hospital, Saudi Arabia
Ibn Sina National College, Saudi Arabia
King Abdulaziz University, Saudi Arabia
King Abdulaziz University, Rabigh, Saudi Arabia

Posters & Accepted Abstracts: Int J Anesth Pain Med

DOI: 10.21767/2471-982X-C1-003

Abstract

Background: Two oral antifungal agents, griseofulvin and terbinafine, have regulatory approval but it is unknown whether one has superior overall efficacy. Genus-specific differences in efficacy are believed to exist for the two agents. It is not clear at what doses and durations of treatment these differences apply. Purpose: The purposes of this meta-analysis were to determine whether a statistically significant difference in efficacy exists between these agents at a given dose and duration of each in tinea capitis infections overall and to determine whether a genusspecific difference in efficacy exists for these two treatments at a given dose and duration of each. We performed a literature search for clinically and methodologically similar randomized controlled trials comparing 8 weeks of griseofulvin (6.25�?¢�?�?�?�?12.5 mg�?¢�?�?�?kg�?¢�?�?�?day) to 4 weeks of terbinafine (3.125�?¢�?�?�?�?6.25 mg�?¢�?�?�?kg�?¢�?�?�?day) in the treatment of tinea capitis. A meta-analysis was performed using the Mantel�?¢�?�?�?�?Haenszel method and random effects model; results were expressed as odds ratios with 95%. Results: Meta-analysis of randomized controlled trials did not show a significant difference in the overall efficacy of the two drugs at the doses specified, but specific efficacy differences were observed based on the infectious species. For tinea capitis caused by Microsporum spp., griseofulvin is superior (p=0.04), whereas terbinafine is superior for Trichophyton spp. infection (p=0.04). Conclusion: Our results support species-specific differences in treatment efficacy between griseofulvin and terbinafine and provide a clinical context in which this knowledge may be applied.

Biography

Nawal Hatem Herzallah has completed her Medical Degree from Royal College of Surgeons in Ireland, Dublin. She is currently a Medical Intern at King Fahd Hospital of the University in Khobar, Saudi Arabia.

Email: nawalhherzallah@hotmail.com