Journal of Obesity & Eating Disorders

FTO gene affects obesity and breast cancer through similar mechanisms: A new insight into the molecular therapeutic targets

15^th International Conference on Obesity Medicine
October 30-31, 2017 Bangkok, Thailand

Maryam Gholamalizadeh and Saeid Doaei

Shahid Beheshti University of Medical Sciences, Iran National Nutrition and Food Technology Research Institute, Iran

Posters & Accepted Abstracts: J Obes Eat Disord

DOI: 10.21767/2471-8203-C1-006

Abstract

The fat mass and obesity-related (FTO) gene is known to be associated with risk of obesity. Some recent studies have shown that the FTO polymorphisms are linked with breast cancer. This review focuses on the possible mechanisms of the effects of the FTO on obesity and breast cancer. All articles published in English from June 1990 to January 2017 were studied. The search terms used were FTO gene, FTO polymorphism, breast cancer and obesity. Inclusion criteria consisted of assessment of the relationship between FTO polymorphisms and/or FTO expression level with obesity and/or breast cancer as a primary outcome. The risk of both obesity and breast cancer is affected by the FTO genotype. Some FTO polymorphisms exert their effects through effect on IRX3 gene expression level. On the other hand, the FTO gene expression level is closely related to mTOR signaling pathway activation and its ultimate effects on obesity and breast cancer. Obesity and breast cancer might have similar genetics origins. The FTO gene is a possible mediator between obesity and breast cancer. If this result is correct then, it will be interesting to examine the FTO gene as a molecular therapeutics target.