American Journal of Pharmacology and Pharmacotherapeutics

Formulation and evaluation of chronotherapeutic pulsatle drug delivery system

European Congress on Pharma
August 13-14, 2018 Paris,France

Sagar D Kadam, Shashikant Dhole and Sohan Chitlange

Savitribai Phule Pune University, H S B P V T��?s GOI, College of Pharmacy, Kashti, Maharashtra, India S N Dhole Savitribai Phule Pune University, P E S, Modern College of Pharmacy, Pune, India Savitribai Phule Pune University, Dr D Y Patil Institute of Pharmaceutical Sciences & Research, Pune, India

Posters & Accepted Abstracts: J Pharmacol Pharmacother

DOI: 10.21767/2393-8862-C1-003

Abstract

The aim of present investigation was to develop press coated tablet for pulsatile drug delivery of Salbutamol sulphate using hydrophilic and hydrophobic polymers. The drug delivery system was designed to deliver the drug at such a time when it could be most needful to patient of rheumatoid arthritis. The press coated tablets containing salbutamol sulphate in the inner core was formulated with an outer shell by different weight ratio of hydrophobic polymer (micronized ethyl cellulose powder) and hydrophilic polymers (Glycinemax Husk or sodium alginate). The release profile of press coated tablet exhibited a lag time followed by burst release, in which outer shell ruptured into two halves. Authors also investigated factors influencing on lag time such as particle size and viscosity of ethyl cellulose, outer coating weight and paddle rpm. The surface morphology of the tablet was examined by a scanning electron microscopy. Differential scanning calorimeter and Fourier transformed infrared spectroscopy study showed compatibility between salbutamol sulphate and coating material.