Journal of Clinical and Molecular Endocrinology

Effect of the duration and presence of proteinuria on parameters of ovarian reserve in patients with chronic kidney disease stages 3-4

11^th International Conference on Endocrinology and Diabetology
August 09-10, 2018 Madrid, Spain

Iwona Szydlowska, Aleksandra Marciniak, Agnieszka Brodowska, Marcin Lisak, Sylwia Przysiecka, Jacek Rozanski.

Posters & Accepted Abstracts: J Clin Mol Endocrinol

DOI: 10.21767/2572-5432-C2-006

Abstract

THE AIM OF THE STUDY was to assess the effect of the duration of CKD and presence or absence of proteinuria on ovarian reserve parameters in patients with chronic kidney disease stages 3-4. MATERIALS AND METHODS: The examination included 24 patients ages 23 to 45, all with chronic kidney disease stages 3-4. The examined parameters of ovarian reserve included: transvaginal ultrasonography (to assess AFC and ovarian volume), serum AMH, FSH and E2 assessed in early follicular phase of menstrual cycle. All patients included to the study had been diagnosed with CKD (kidney damage or dysfunction) and had decreased GFR- below 60 ml/min/1.73 m2 for at least 3 months: • moderate reduction in GFR (30–59 ml/min/1.73 m2)- stage 3 of CKD, • severe reduction in GFR (15–29 ml/min/1.73 m2)- stage 4 of CKD. Parameters of ovarian reserve were assessed in patients with chronic kidney disease stages 3-4 depending on the duration of the disease (less or longer than 10 years) and depending on the presence or absence of proteinuria. CONCLUSIONS: 1. Ovarian reserve (ovarian volume, AFC, AMH, FSH and E2) is not dependent on the duration of CKD. 2. Hormonal parameters of ovarian reserve: AMH, FSH, E2 are not dependent on the presence or absence of proteinuria in patients with CKD.

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