Journal of Environmental Research

Effect of increased manganese content in drinking water on the balance of certain neurotransmitters in children

Joint Event on 5^th International Conference on Pollution Control and Sustainable Environment & 10^th Edition of International Conference on Water: Pollution, Treatment & Research
March 14-16, 2019 London, UK

Kol'dibekova Yu, Zaitseva N and Zemlianova

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies Perm, Russia

Posters & Accepted Abstracts: J Environ Res

Abstract

Quality of drinking water is becoming especially vital in industrially developed cities in Russia, USA, Germany as it exerts considerable influence on population health. Manganese (Mn) is among priority contaminants which pollute drinking water. We performed our research on samplings created as per randomized clusterization technique with approximated modeling strategy. Our samplings were made up of children aged 4-7 years who drinking water with increased Mn contents. Mn content assessment results revealed persistent occurrence of this metal in drinking water in quantities equal to 0.81 mg/l or up to 0.4 RfDcr. Chronic exposure of children population was characterized with daily Mn dose being up to 0.002 mg/(kg∙day) introduced orally with drinking water. Approximately 2.000 children aged 0-14, were an exposed sub-population. We detected 1.3-1.4 higher average Mn concentration in blood of children from the focus group against the same parameter in children from the reference group and the reference level (р=0.0001-0.010). On the basis of a relevant model, an increased Mn content in the blood which was higher than the reference level was validated as an oral exposure marker. In assessing the biochemical parameters characterizing the balance of the neuromediators, an increase in glutamic acid and dopamine (excitation neurotransmitters) in blood serum of children from the focus group was found 1.4–1.5 times higher and a decrease in γ-aminobutyric acid (inhibiting neurotransmitter) was found 1.8 times lower than the same indicator in the control group (р=0.0001- 0.001). We proved that increase in glutamic acid and decrease in γ-aminobutyric acid depended on Mn content in blood (OR = 3.4–4.5; 2.2 ≤ DI ≥ 5.8; р=0.0001–0.002; 0.64 ≤ R2 ≥ 0.80; р=0.0001). Chronic exposure to Mn in drinking water causes an increase in the incidence of diseases of the central nervous system in children (about 100 additional cases/1000 children) in the form of an astheno-vegetative syndrome, attention deficit hyperactivity disorder associated with external exposure of Mn to drinking water.

Biography

Kol'dibekova Yu is a senior researcher, head of the metabolism and pharmacokinetics laboratory at the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Candidate of Biological sciences She has published over 60 articles in refereed journals.