Annals of Biological Sciences

Developing human and human-like antibodies for biodefense

ANNUAL BIOTECHNOLOGY CONGRESS
August 17-18, 2017 | Toronto, Canada

Michael Hust

Technische Universit�¤t Braunschweig, Germany

Posters & Accepted Abstracts: Ann Biol Sci

DOI: 10.21767/2348-1927-C1-003

Abstract

Antibody phage display is a key in vitro technology to generate human antibodies. In this presentation, our pipeline for the development of human and human-like antibodies for diagnostics and therapy will be outlined. The development of human and macaque antibodies against category A and B (according to CDC) classified viruses and toxins using phage display will be presented. Detailed examples will be given for diagnostic and neutralization of Venezuelan equine encephalitis virus (VEEV), Western equine encephalitis virus (WEEV), Marburg virus and botulinum toxins (EU FP7 Antibot ABE consortium). In addition, the germline humanization of the anti-botulinum toxin antibodies will be outlined.