Cynarin inhibits melanogenesis through ERK signaling pathway on andalpha;-MSH-induced melanin biosynthesis

Gyoseon Goya M Ryeom; Hae Yeon Kim; Young Bu Kim

doi:10.21767/2348-9502-C1-003

Cynarin inhibits melanogenesis through ERK signaling pathway on α-MSH-induced melanin biosynthesis

Joint Event on 3^rd World Congress on NATURAL PRODUCTS CHEMISTRY AND RESEARCH & 12^th WORLD PHARMA CONGRESS
October 16-18, 2017 Budapest, Hungary

Gyoseon Goya M Ryeom, Hae Yeon Kim and Young Bu Kim

iPEERES Cosmetics Ltd., Republic of Korea

Posters & Accepted Abstracts: Am J Ethnomed

DOI: 10.21767/2348-9502-C1-003

Abstract

Cynarin is composed of plant such as artichoke, sunflower seed and burdock. These materials have compound such as chlorogenic acid (Caffeoylquinic Acid), caffeic acid, cynarin (Dicaffeoylquinic Acid), quercitrin (Quercetin Rhamnoside), arctiin, quercetin, luteolin. They provide special bio-physiological effect: chlorogenic acid, caffeic acid, quercitrin and luteolin as anti-melanogenesis factor; arctiin as inflammatory regulator (MAPK related factor) or protector from UVB-induced stress and so on. However, it has not been reported yet for melanogenesis biosynthesis of cynarin as component of these plants. Therefore, we also investigated melanogenesis of cynarin via signaling pathway. Melanogenesis-related protein as MITF, tyrosinase were decreased by cynarin via ERK signaling pathway in α-MSH-induced human melanoma cells (MNT-1). Cynarin has also represented inhibition of melanin content and intracellular tyrosinase activity. Cynarin is being provided at antimelanogenesis or anti-pigmentation factors because of its investigated anti-melanogenesis mechanism in α-MSH-induced human melanoma cell and are well worth enough.