International Journal of Anesthesiology & Pain Medicine

Association of IGF-I gene polymorphism with diabetic nephropathy in Egyptians with Type 2 diabetes

Joint Event on 7^th Edition of International Conference on Internal Medicine and Patient Care & 6^th Edition of International Conference on Pain Management
March 26-28, 2018 Vienna, Austria

Eman H EL-Adawy Mohamed A Hegazi, Amal Seleem, and Mahmoud E Abdelhamid

Specialized Medical Hospital - Mansoura University, Egypt Mansoura University Hospital, Egypt Tanta Univeresity, Egypt

Posters & Accepted Abstracts: Int J Anesth Pain Med

DOI: 10.21767/2471-982X-C1-003

Abstract

Background: Genetic susceptibility has been proposed in development and progression of diabetic nephropathy (DN) which accounts for the majority of chronic renal failure on hemodialysis among Egyptians. IGF-1 gene polymorphism has been studied in DN in type 1 diabetes but not yet in type2. Aim: The aim of this study is to investigate the association of IGF1 gene polymorphism with DN in Egyptians with T2DM. Methods: A case control study of 52 T2DM were divided into 26 without DN and 26 with DN, of average age 52.7�?±6.1. Twenty five age and sex matched healthy control were selected. We genotyped two tagging single nucleotide polymorphisms (SNPs) in IGF-1; rs6214 and rs10860860. Genotypic distribution was tested for Hardyâ�?�?Weinberg equilibrium and was evaluated by using the Ï�?2 tests. Participants were assessed clinically and laboratory for FBS, HBA1c, serum creatinine, urine albumin, uric acid and lipid profile. Results: The genotype frequency GG of IGF-1 gene SNP rs6214 was associated with the risk of DN (AA: OR=0.98, 95% CI: 0.25 â�?�? 3.84, p = 0.97; AG: OR=0.21, 95% CI: 0.05 â�?�? 0.79, p = 0.002; GG: OR= 20.57, 95% CI: 2.25 â�?�? 74, p = 0.001). The AA variant genotype of rs10860860 also associated with the risk of DN (AA: OR=7.37, 95% CI: 1.87 â�?�? 30.07, p = 0.001; AT: OR=0.20, 95% CI: 0.05 â�?�? 0.78, p = 0.007; TT: OR= 0.29, 95% CI: 0.01 â�?�? 3.59, p = 0.28). Conclusion: The variants of rs6214 and rs10860860 in IGF-1 gene entail the risk of DN in Egyptians with T2DM.

Biography

Eman H EL-Adawy has completed Her MD from Mansoura University. She is a Associate Professor of Internal Medicine and Endocrinology Department in Spescialized Medical Hospital,Faculty of Medicine, Mansoura City, Egypt. She published more than 10 papers in reputed journals.

Email:emaneladawy@yahoo.com