Journal of Organic & Inorganic Chemistry

Antibacterial naphthalene-based agents

2^nd Edition of EuroSciCon Conference on Chemistry
February 19-20, 2019 | Prague, Czech Republic

Josef Jampilek

Comenius University, Slovakia

Posters & Accepted Abstracts: J Org Inorg Chem

DOI: 10.21767/2472-1123-C1-021

Abstract

Although naphthalene can be considered as the simplest compound from the group of arenes, it is one of the most interesting arenes. Naphthalene-based drugs include not only clinically used anti-infective chemotherapeutics, but also other agents with significant antimicrobial properties. The naphthalene scaffold can be found in several other therapeutic classes such as antidepressants, nonsteroidal anti-inflammatory drugs, α1-adrenomimetrics, α1-adrenolytics, β1-adrenolytics and peroral antidiabetics. Thus, it can be stated that this scaffold can be considered as a privileged structure. The naphthalene scaffold can be easily and rapidly functionalized, which provides a possibility of a great number of targeted modifications as well as modification/ optimization of physicochemical properties. This contribution is focused especially on the investigation of ring-substituted hydroxyl naphthalene carboxamide derivatives that expressed promising biological activities as antibacterial agents against a number of human pathogens. Structure-activity relationships and the supposed mechanism of action are discussed.

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