American Journal of Ethnomedicine

Anti-aggregant effect of Rubia tinctorum extracts on platelets in vitro and ex vivo

7^th Edition of International Conference on Pharmacognosy and Medicinal Plants
March 11-12, 2019 London, UK

Fatima Zahra Marhoume, Abdellah Bagri, Hicham Boufous, Mehdi Ait Laaradia and Abderrahman Chait

Universite Hassan-Ier, Morocco University Cadi Ayyad, Morocco

ScientificTracks Abstracts: Am J Ethnomed

DOI: 10.21767/2348-9502-C1-008

Abstract

Platelets play pivotal role in primary hemostasis and several cardiovascular diseases (CVD) in atherothrombotic disease and are associated with an increase in blood platelets aggregation. Rubia tinctorum (RT) extracts was investigated for anti-aggregant activity induced by collagen in vitro and ex vivo by measuring the bleeding time and platelets count. Our finding demonstrated that RT extract showed a significant (P<0.001) inhibition of collagen induced platelets aggregation (1.48±0.76, n=3). This results correlate well with data of bleeding time and platelet count. Phytochemical analysis revealed the presence of flavonoids which may be implicated in this action.

Biography

Fatima Zahra Marhoume currently working as a professor in Laboratory of Pharmacology, Neurobiology and Behavior, Semlalia Faculty of Sciences, Cadi Ayyad University, Marrakech, Morocco.