Dentistry and Craniofacial Research

An x-ray microtomography measurement of a novel bioactive glass varnish in prevention of white spot lesions. (A comparative acid challenge study)

25^th International Conference on Dental Treatment
September 10-11, 2018 Zurich, Switzerland

Thaer Jaber Al-Khafaji, Ferranti Wong, Padhraig S. Fleming and Robert Hill

Department of Dental Physical Science, London Barts and the London Dental School, School of Medicine and Dentistry, London

Posters & Accepted Abstracts: J Dent Craniofac Res

DOI: 10.21767/2576-392X-C3-009

Abstract

Background: White spot lesion (WSL) represents the early manifestation of the dental caries and can be treated by a noninvasive management. The white spot lesion is still the most complicated dilemma facing orthodontists during orthodontic treatment using fixed appliances. Light cured bioactive glass varnishes releasing calcium, phosphate, strontium and fluoride for controlled remineralisation exhibit promise for prevention of WSL. Objectives: To evaluate in vitro the effectiveness of application of novel BAG varnish in the protection of enamel surfaces against acid challenge. Materials and Methods: A total of 6 enamel blocks were selected and distributed randomly into two groups (n = 3). Group A: ClinproTM white varnish (3M ESPE TM) was used to coat the enamel surface and group B: light cured BAG varnish which consists of BAG (35% SiO2, 45% CaCO3, 7.5% Na2CO3, 6% P2O5, 6% SrF2) mixed with resin (70/30 UDMA/HEMA, 0.6% EDMAB, 0.3% CQ, and 1% 4META) with glass: resin ratio of 60:40 was used. The enamel blocks were covered with two layers of acid-resistant nail varnish except the exposed enamel surface. Each three enamel blocks were mounted vertically in small plastic tubes and scanned by XMT before and after immersion in 10ml artificial saliva demineralising buffer (pH = 4) over two time periods 24 hours and 96 hours at 37ºC. Result: The evaluation of XMT slices demonstrated the ability of the BAG varnish to prevent the development of WSL after immersion in AS pH4 for 24 hours and 96 hours. The line profiles have confirmed the protective efficacy of BAG varnish in reducing the acid demineralisation. Conclusions: This ex-vivo acid challenge study illustrates that the novel BAG varnishes can be used effectively to prevent the WSL and protect the teeth from low pH environment in oral cavity. Hence, the novel BAG varnish has the potential to prevent demineralisation and caries.

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