Journal of Organic & Inorganic Chemistry

Addressing the opioid crisis by developing analgesic drugs with novel modes of action

European congress on Advanced Chemistry
July 12-13,2018 Paris ,France

Sylvie Ducki

Sylvie Ducki Universite Clermont Auvergne, Institut de Chimie de Clermont-Ferrand, Clermont-Ferrand, France

ScientificTracks Abstracts: J Org Inorg Chem

DOI: 10.21767/2472-1123-C2-005

Abstract

Chronic pain affects 1.5 billion people worldwide, causing a great deal of discomfort among patients and an enormous economic and societal burden. Inadequate pain control, undesirable side-effects associated with current analgesics as well the recent opioid crisis have revived interest in analgesic drug development. The challenge is to develop original analgesics with novel modes of action to address the unmet needs of patients. Pichon recently reported that disrupting the interaction between the PDZ-containing protein PSD-95, and the endogenous ligand 5-HT2A receptor, reduced hyperalgesia suggesting inhibition of this PDZ protein could result in analgesia. Devilliers reported that TWIK-Related K+ channel TREK-1 -/- mice were more sensitive than wild-type TREK-1 +/+ mice to painful stimuli, suggesting that activation of TREK-1 could result in pain inhibition. Various approaches of drug discovery were explored in order to develop original analgesic drugs targeting PSD-95 and TREK-1.

Biography

Sylvie Ducki has completed her PhD from the University of Manchester (UK) and Postdoctoral studies at the Arizona State University (USA). She joined the University of Salford for a 6-year lectureship and has been a Professor in Organic and Medicinal Chemistry at Sigma Clermont (France) for 11 years. She has published more than 60 papers in reputed journals and has been serving as an Editorial Board Member of various journals including Anti-Cancer Agents in Medicinal Chemistry, Current Chemical Biology, Medicinal Chemistry.

E-mail: Sylvie.Ducki@Sigma-Clermont.fr