Winston GariraProfessor
Biography
I am a active researcher in Biomathematics on the African continent currently based in
South Africa. My interest in Biomathematics started in 2002. This has led to a number
of research projects most of which are still ongoing. Currently, I am working on multiscale
modelling of infectious disease systems. Infectious disease systems typically involve processes
at multiple scales, from gene to molecules to cell to tissue or organ or organism and
the environment. Studies of any single scale are not sufficient to describe the complete
disease system. Multiscale modeling is becoming an increasingly important approach to
studying disease systems. The multiscale modeling research for my research involves formulating
mathematical models intended to trace the life cycle of infectious pathogens such
HIV, MtB etc. over three scales which are: within-cell scale (which involves the replication
and persistence of pathogens within cells), between cells scale and the between-human hosts
scale. IMy research involves developing tractable predictive multiscale models of infectious
disease transmission dynamics in which within-host processes (intracellular and intercellular)
and infection dynamics interact both ways through inoculum size and reinfection in the initial infection stages. The overall aim of the research is to develop multiscale models
of infection and treatment in which events inside of infected cells are modeled as well
spread of pathogen among cells including the transmission of pathogen between human
hosts. Until recently, mathematical modelling of infectious diseases has focused on single
scale (immunological models, epidemiological models, organ level, etc.). This is despite the
fact that infectious diseases are multi-scale, multi-science systems which bridge a wide variety
of temporal and spatial scales. Infectious diseases modelers are increasing turning
to multi-scale modelling. The central idea in multi-scale modelling is to divide a modelling
problem such as an infectious disease system like HIV/AIDS into a family of sub-models that
exist at different scales and then attempt to quantitatively study a significant portion of the
problem at these scales while fundamentally linking the sub-models across these scales.
However, this divide-and-rule strategy poses new challenges in terms of strategies for problem
decomposition and solution strategy, scale separation and coupling, integration and
coupling of mechanistic and phenomenological models and validation of multiscale models.
We define multi-scale modelling as a modelling methodology in which a collection of partial
models or sub-models are integrated using a wide range of integration frameworks. Currently,
much of multi-scale modelling of infectious diseases concentrates on the lower scales
with models of genes, proteins, carbohydrates, lipids, signaling pathways and networks,
metabolic pathways and networks molecular integrations at the cellular level. My current
multi-scale modelling research provides a platform for linking these lower-scale level models
with higher-scale models for understanding infectious diseases.
Research Interest
Biomathematics, Infectious disease, epidemiological models, genes, proteins, carbohydrates
Global Experts in the subject
A.N. Ihab
A.Pce
APARNA JAISWAL
Abdel Aziz A. Ghanem
Abdul Rashid
Abdulaziz A. Zorgani
Abdulaziz Zorgani
Abdulhamid M. Alkout
Abdullmonem A Ramadhan
Abedi G
Adamakidou Theodoula
Adenike AO Ogunshe
Adetayo Ebun TALABI
Adina Baciu
Adriana Fernandes da Silva
Ahmad Abir Ab. Ghani
Ahmad Faris
Ahmed I. Albarrak
Aijaz Ali
Ajuwon Ademola Johnson
Alamanou Despoina
Alfiya Aminova
Ali Asghar
Amela Dervisevic
Amela Kulenovi
Amudha Kadirvelu
Andrea S Torrïÿýo
Anisodowleh Nankali
Ankad Roopa B
Ankur Barua
Ankur Joshi
Annie Jojo
Anup N. Nillawar
Argyropoulos Evangelos
Aristomenis Kossioris
Arun Kumar
Arunpreet S Kahlon
Arushi Agarwal
Asha K K
Asha Pratinidhi
Ashok Kumar Biswas
Astha Nigam
Aswir Abd Rashed
Atay B
Atif Rahman
Avnish Kumar
Aye Aye San
Aye Mya Thidar
Azadeh Amiri Rigi
Azlina Ishak
Azza Abdel-Aziz
Azza Ibrahim
B Raghu
Bashirah Ishak
Basilio Vagner
Belgherbi A.
Bernadit Sarraf
Bessaid A.
Bibek Poudel
Bilal Karim Siddiqui
Binu VS
Boushab MB
Béla Dénes
C.R. Anand Moses
Cai Liam Tam
Chairil Anwar
Chamil Vidusha Madushan Jinadasa
Chao-Chia Weng
Cheng-Hsi Su
Ching-Zong Wu
Christie .A. Enuku
Chunhua song
Dr. Caroline Lodge
Dr. Fabio Fumagalli
Dr. Francisco Javier Callejas Gonzalez
Dr. Julie Renwick
Dr. Peter Neils Le Souef
Dr. Valerie Urbach
Indranil Chakrabarti
Khosbayar Tulgaa
Reiko Nishihara