Assay Director
McDevitt Laboratory
BioScience Research Collaborative
Rice University

Dr. Nicolaos Christodoulides serves as the Assay Director for the bio-nano-chip project at the McDevitt Laboratory at the BioScience Research Collaborative at Rice University. Dr. Christodoulides is one of the inventors in a large portfolio of patents related to the development of the membrane- and bead-based integrated lab-on-a-chip methods and bio-nano-chip technologies. The same platform developed for cellular analysis was applied for the enumeration of white blood cells, a test that when combined with the bead-based counterpart ultra-sensitive C-reactive protein assay, which was co-developed by Drs. McDevitt, Floriano and Christodoulides, is expected to contribute to a more accurate assessment of risk for future cardiovascular events. Dr. Christodoulides directs research activities related to assay development, validation and implementation in the McDevitt Laboratory. He provides strategic direction for product design and development, as well as co-ordinates both analytical and clinical validation of the high performance assays intended for the point of care. Since he joined the McDevitt Laboratory in 2000 as a senior scientist, Dr. Christodoulides has directed the development and validation of more than 30 lab-on-a-chip assays, including the usCRP test, as well as multiplexed assays for cardiovascular disease (risk assessment, diagnosis and prognosis of acute myocardial infarction), allergy testing, toxin detection and serum to saliva contamination tests. He has also directed the first implementation of single chain variable fragments on the lab-on-a–chip assay platform and the application of select assays for the testing of clinical samples, including those associated with the initiative of using saliva as a diagnostic fluid for oral and systemic disease. He now serves as a project manager for the on-going, National Institute of Dental and Cranofacial Research (NIDCR)-funded 588 patient clinical trial “Development of a Lab-on-a-Chip System for Saliva-Based Diagnostics”, a study conducted in collaboration with Dr. Christie Ballantyne and Dr. Biykem Bozkurt of Baylor College of Medicine (BCM).

Biotechnology, Immunology, Bioengineering, Hematology, Nanobiotechnology, Biomedical Science, ELISA, Bioscience