Abstract

Received: May 13 ,2022; Accepted: May 20,2022; Published: May 27,2022

Posttraumatic stress disorder (PTSD) is a trauma and stressor related disorder characterized with specific clusters of symptoms including cognitive disturbances. Brain derived neurotrophic factor (BDNF) is a neurotrophin with important role in modulation of neuronal growth, plasticity, neurotransmission, stress response and cognition (learning, memory), all processes are altered in PTSD. The study included 333 male Caucasians with combat-related current and chronic PTSD. They were evaluated using SCID, PANSS, CAPS, and two PANSS cognitive subscales: PANSS Cognition subscale 1 and PANSS Cognition subscale 2. Genotyping of the BDNF Val66Met (rs6265) and BDNF C270T (rs56164415) was done using the primers and probes from the TaqMan® Drug Metabolism Genotyping Assays on ABI Prism 7300 Real time PCR System apparatus (Applied Biosystems, Foster City, CA, USA) in DNA samples. Results were evaluated using Kruskal-Wallis ANOVA and Dunn post-hoc test, or Mann Whitney U test, or χ2 –test.