Abstract

Nanotechnology is a cutting-edge field that spans many possibilities for the study and treatment of different diseases. A key tool recently developed in biomedical engineering research thanks to this technology is organ-on-chip (OoC) platforms. OoC is a low-cost and easy-to-work animal-free in vitro model that simulates the physiological response, considering mechanics and activity, of entire organ systems or part of them, for the study of human physiology (healthy and diseased) in a specific context of the organ. These platforms integrate, by nano and microfabrication techniques, microfluidics, multicellular 3D tissue, and monitoring integrated systems. Moreover, these micro-physiological systems permit the use of patient induced cells, using human Induced Pluripotent Stem Cells (hIPSC) will be a key tool for personalized pathophysiological study in vitro, and for permeability assessments of drug delivery for tailoring drug selection and dose I mimicked body barriers. In this talk an overview of OoC technologies that integrates sensor systems for a continuous monitoring of the evolution of the micro physiological platform will be presented. Future trends and advantage and limitations of this technology will be discussed.