Renal Cell Carcinoma: Pathophysiology and Molecular Mechanism

Shinya Thomas*

Department of Nephrology, Medical University Vienna, Vienna, Austria

*Corresponding Author:
Shinya Thomas
Department of Nephrology, Medical University Vienna, Vienna,
Austria,
E-mail: thomas@gmail.com

Received date: April 12, 2024, Manuscript No. IPJRM-24-19161; Editor assigned date: April 15, 2024, PreQC No. IPJRM-24-19161 (PQ); Reviewed date: May 06, 2024, QC No. IPJRM-24-19161; Revised date: May 13, 2024, Manuscript No. IPJRM-24-19161 (R); Published date: May 20, 2024, DOI: 10.36648/ipjrm.7.3.25

Citation: Thomas S (2024) Hereditary Papillary Renal Cell Carcinoma and von Hippel-Lindau Disease as Genetic Gateways for Kidney Cancer. Jour Ren Med Vol. 7 No.3: 25.

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Description

Kidney cancer, medically known as Renal Cell Carcinoma (RCC), is a malignancy that originates in the kidneys, vital organs responsible for filtering blood and removing waste through urine production. However it represents just a little level of all disease analyze, kidney malignant growth positions among the best ten most normal tumors internationally. RCC is the most common type of kidney cancer, accounting for approximately 9 out of 10 cases. Transitional Cell Carcinoma (TCC) affects the renal pelvis or ureters, the tubes that carry urine from the kidneys to the bladder. This type of kidney cancer is less common than RCC but requires specialized treatment approaches. It originates in the developing cells of the kidney and is highly treatable with early detection and appropriate therapy.

Kidney cancer

Kidney cancer can indicate in several forms, with renal cell carcinoma being the most prevalent. Other less common types include transitional cell carcinoma and Wilms tumor, typically diagnosed in children. Renal cell carcinoma arises from the cells lining small tubes within the kidney called tubules. These cells mutate and grow uncontrollably, forming a tumor. Smoking, obesity, and high blood pressure are prominent risk factors, along with a family history of kidney cancer and certain genetic conditions such as Von Hippel-Lindau (VHL) disease and hereditary papillary renal cell carcinoma. Exposure to certain chemicals, such as asbestos and organic solvents, may also contribute to the development of kidney cancer. Early-stage kidney cancer often presents no symptoms, making it challenging to detect. However, as the disease progresses, symptoms may manifest, including blood in the urine, persistent back pain below the ribs, unintentional weight loss, fatigue, and intermittent fever. Advanced-stage kidney cancer can lead to additional symptoms such as swelling in the legs or ankles, high blood pressure, and anemia. Diagnosing kidney cancer typically involves a combination of physical examination, medical history review, imaging tests (such as ultrasound, CT scan, or MRI), and biopsy. Staging, which determines the extent of the cancer's spread, is crucial for treatment planning. Kidney cancer staging ranges from stage I (localized tumor) to stage IV (cancer has spread to distant organs or lymph nodes).

Treatment of Kidney cancer

Treatment for kidney cancer varies depending on the stage of the disease, overall health, and patient preferences. Surgical interventions, such as nephrectomy or partial nephrectomy, are common approaches for localized kidney cancer. Advanced-stage kidney cancer may require additional treatments, including targeted therapy, immunotherapy, radiation therapy, chemotherapy, or participation in clinical trials investigating advancements treatments. The prognosis for kidney cancer patients depends on several factors, including the stage of the disease at diagnosis, tumor characteristics, overall health, and response to treatment. While early-stage kidney cancer often has a favorable prognosis, advanced-stage disease poses greater challenges. With advancements in treatment modalities and ongoing research efforts, survival rates for kidney cancer have improved in recent years. A kidney cancer diagnosis can be emotionally and physically challenging for parents. Engaging in support groups, seeking counseling or therapy, and adopting healthy lifestyle habits including regular exercise, nutritious diet choices, and stress management techniques can aid in coping with the disease's impact and treatment-related side effects. Additionally, healthcare providers play a essential role in providing support, guidance, and access to resources throughout the cancer journey. Continued research into the molecular mechanisms underlying kidney cancer, along with advancements in precision medicine and immunotherapy, holds promise for improving treatment outcomes and enhancing the quality of life for kidney cancer patients. Clinical trials investigating novel therapies and personalized treatment approaches are essential for advancing our understanding of kidney cancer and developing more effective treatment strategies.

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