Abstract

Autism disorder has complex and heterogenous neurodevelopmental pathologies with immune system dysfunction. Autism basically deprives ones communication and social skills including immune abnormalities and neural hypoperfusion. They also cause inflammation manifesting in serum levels of macrophage infected cytokine and thymine altering cytokine. Several factors in neurobiology, changes the application and concept to a more adaptive approach. The best method of them is the cell based therapy. Stem cells have shown potential immunological properties, hence they are helpful in treatment. Molecular and regenerative aspects holds a greater expectations for therapy of Autism spectrum disorder(ASD). This review will focus on stem cell based therapy for ASD in which cells can be potentially designed to target abnormal neurotransmitter, activated microglia, dysfunction membrane in brain, pancrine immumodulatiry effects, blood brain barrier disruptions.