Heart attack is mainly caused due to atherosclerosis. It is a coronary artery disease (CAD) and it is a leading cause of death worldwide. It occurs when the coronary artery that supplies blood and oxygen to the heart and different parts of the body becomes blocked or narrowed due to deposition of proteins, cholesterol and other fatty deposits in the inner wall of the coronary artery. This results in a heart attack or damage to the heart tissue. Existing techniques for detection of plaque are Magnetic Resonance Imaging (MRI), Electron Beam Computed Tomography (EBCT) and Angiography, among these existing techniques Angiography is widely used at present to detect and cure heart attack. The currently available techniques are expensive, beyond the reach of normal people, not easily available in remote areas and cannot detect deeply embedded plaque with accuracy at early stages. The plaque is only detected by these techniques when blockage in artery is more than 70%. In order to remove the limitations of existing techniques Intravascular Ultrasound (IVUS) technique is proposed in our research work. This technique is based on application of image processing by using bio-markers and Marker Controlled Watershed Modified Image Segmentation Algorithm which better detects the Plaque deposits embedded deep inside the Coronary Artery wall that are undetectable by Angiography or other Cardiac test that are prone to rupture without warning sign. In addition to this technique Artificial Intelligence (Deep Learning) computing technique will also be used for image classification.