Abstract

"Mesotherapy" is a non-surgical, minimally invasive method, which can be done with the use of blood derivatives that consists of multiple intradermal or subcutaneous injections stimulating the body's natural healing cascade, yielding visible results within a short period of time. Platelet Rich Fibrin is the latest generation of blood derivatives and it can be in a liquid form able to enhance healing after facial procedures, as well as to rejuvenate the face without tissue manipulation. i-PRF+ utilizes activated platelets, inflammatory cells and stem cells found in our blood for regeneration of skin and ultimately alleviate wrinkles. The release of cytokines associated to the niche of mesenchymal stem activate as well the regenerative process and angiogenesis for better oxygenation of the skin, in order to convert the stem cells in mature cells. This procedure begins the production of collagen and elastin fibers which is helped by the fibrin matrix produced naturally from the soluble fibrinogen (A-PRF). Moreover, the plasma contains proteins, minerals, vitamins and other nutritional substances, which lead to skin rejuvenation.