Abstract

The treatment of diabetic wounds remains one of the major challenges in clinical practice, due to the multiple drug-resistant bacterial infections, angiopathy, and oxidative damage to the microenvironment. Herein, we sought to introduce a novel in-situ injectable HA@MnO₂ hydrogel to accelerate the diabetic wound healing. Through the convenient injection, this hydrogel can form a protective dressing covering the wound to provide rapid haemostasis and long-term antibacterial. Meanwhile, the MnO₂/ e-PL nanosheet catalyze the overexpressed H₂O₂ in wound to convert to O₂, so that eliminating the harmful effect of H₂O₂ and providing enough O₂ for wound healing. Moreover, the following releasing of M2-derived Exosome (M₂ Exo) and FGF-2 growth factor constantly simulate the angiogenesis and epithelization, respectively. The in vivo and in vitro results determined an accelerated diabetic wound healing using HA@MnO₂ hydrogel, which representing a versatile strategy for repairing a wide range of diabetic tissue damages.