Abstract

Transcriptional variability is necessary for normal gene expression but it is also a liability when the gene profiles generated are cancer profiles. This is true for DNA transcription as well as RNA translation. Methylation can interfere with transcription and alter micro RNA translation or cleave RNA. This can lead to cellular transformation tumor genesis as in HPV. Viral oncogene methylation can repress tumor suppressor genes. We also see epigenetic potential of known carcinogens and mutagens needs to be assessed and included in carcinogen determinations and their regulation. Generational heritability also needs assessment.