Abstract

 Lab-on-Chip technology is gaining great interest due to the many possibilities that it offers in the fields of life sciences, from parallel analysis in genomics to point-of-care devices in medical diagnostics. At the beginning, Lab-on-Chip devices essentially consisted of a microfluidic network that miniaturized the analytical procedures leading to faster reaction kinetics and lower sample and reagents consumption. Recent devices integrate on a single substrate several functional modules, that allow all the functions of a human-scale test laboratory including transferring samples, drawing off a precise volume of a chemical product, reagent mixing, detection and quantification of biomolecules.

    Within this framework, this work focuses on the development of a lab-on-glass system based on thin film optoelectronic devices and thick film microfluidics. Indeed we have integrated, on a single glass substrate, p-i-n amorphous silicon structures acting as photosensors and temperature sensors for for on-chip detection and temperature control and optical filters for selection of specified wavelength.

 This glass substrate coupled with a microfluidic network made in polydimethylsiloxane (PDMS) or pressure sensitive adhesive layer, and connected to custom electronic boards, enables  applications in the field of mycotoxin detection and DNA amplification of bacteria and virus.