The Erector Spinae Plane Block (ESPB) is a newer regional anesthetic technique that can be used to provide analgesia for a variety of surgical procedures or to manage acute or chronic pain. ESPB is relatively easy to perform with minimal or no sedation in the pre-operative holding area. This case report shows that ESPB can be used as an effective and safe anaesthesiological alternative in fragile patients with multiple comorbidities.