Abstract

The gut-brain axis (GBA) consists of bidirectional communication between the central and also the enteric system nervous, linking emotional and cognitive centers of the brain with peripheral intestinal functions. Recent advances in research have described the importance of gut micro biota in influencing these interactions. This interaction between micro biota and GBA appears to be bidirectional, namely through signaling from gut-micro biota to brain and from brain to gut-micro biota utilizing neural, endocrine, immune, and humoral links. The present review, summarize the available evidence supporting the existence of those interactions, further because of the possible pathophysiological mechanisms involved. Most of the info is acquired using technical strategies consisting of germ-free animal models, probiotics, antibiotics, and infection studies. In clinical practice, evidence of micro biota-GBA interactions comes from the association of dysbiosis i.e.