Brief Note on Natural Treatments for Psoriasis

James Saremirad

Brief Note on Natural Treatments for Psoriasis

James Saremirad^*

Department of Pharmacology, University of Papua New Guinea, Port Moresby, Papua New Guinea

*Corresponding Author:: James Saremirad
Department of Pharmacology, University of Papua New Guinea, Port Moresby, Papua New Guinea
Email: JamesSaremirad@gmail.com

Received date: December 02, 2021; Accepted date: December 16, 2021; Published date: December 23, 2021

Citation: Saremirad J (2021) Brief Note on Natural Treatments for Psoriasis. Am J Ethnomed Vol.8 No.11: 004.

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Keywords

Psoriasis; Mobileular; Disorder; Symptoms

Introduction

Psoriasis types and symptoms

There are five main types of psoriasis, namely: plaque psoriasis, guttate psoriasis, inverse (flexural) psoriasis, pustular psoriasis, and erythrodermic psoriasis [1] . A part from these, nail psoriasis is present, which is localised to the nails only, and psoriatic arthritis is limited to joint and connective tissue inflammation. The main symptoms are irritation with red and flaky patches of skin. Patches are most often seen on the elbows, knees, and middle of the body, but can appear on the scalp and elsewhere in th e body [2]. The skin may be itchy, is pink or red in color. Other symptoms include genital sores, joint pain, thickening and browning of nails, and severe dand ruff the scalp [3] .The disorder is so severe that it often needs lifelong treatment. Apart from the various predicted reasons for psoriasis to induce, drug-induced psoriasis is more common and is explored next to this [4,5].

Alternative natural treatments for psoriasis

Capsicum annuum/ Capsicum frutescens: It is commonly known as "Cayenne," its chief component being capsaicin. One hypothesis on the pathogenesis of psoriasis suggests a neurogenic inflammatory aetiology mediated through Substance P (SP). SP activates inflammatory cells and ultimately perpetuates vasodilatation, angiogenesis, and keratinocyte hyperproliferation. Accordingly, psoriatic lesions are more densely innervated and have a higher SP content than control or uninvolved psoriatic skin. Capsaicin stimulates the release of SP by binding to the vanilloid receptor on slow-conducting, unmyelinated type C neurons and ultimately leads to its depletion.

Aloe vera: Aloe vera is a popular plant used in and first aid products in the case of thermal injuries. Aloe vera contains anthroquinones, steroids, saponins, mucopolysaccharides, and salicylic acid. Syed and colleagues (1996) conducted a double-blind, placebo-controlled study on 60 patients with psoriasis with slight to moderate plaque type psoriasis and an average 8.5-year duration of their disease. For four weeks, patients applied topical vehicle placebo to their psoriatic plaques without occlusion. The aloe group showed significantly higher rates of clearing the psoriatic plaques in almost all patients. Anthraquinone and acemannan, the main active ex tract cream or compounds in Aloe vera, have antibacterial activity against Staphylococcus and Streptococcus species and may provide a rationale for their therapeutic efficacy in psoriasis. In addition, salicylic acid, a component of Aloe vera, is keratolytic and would contribute to its reported efficacy in the desquamation of psoriatic plaques [6].

Silybum marianum: Milk thistle It is commonly known as milk thistle. This plant is well known for its liver-protecting effect. Many changes have been observed in the livers of patients with psoriasis, including steatosis, inflammation around the portal vein, fibrosis, necrosis, and cirrhosis. The multifactorial aetiology of liver disease in patients with psoriasis includes changes due to alcohol intake, dietary factors, anti-psoriasis drugs, and the direct effects of psoriasis itself. Abnormally high levels of cAMP and leukotrienes are observed in patients with psoriasis, and these levels can occur to improve the condition. The importance of silymarin in the treatment of psoriasis may be due to its ability to enhance hepatic endotoxin clearance, inhibit cAMP phosphodiesterase, and inhibit leukotriene synthesis.

Angelica sinensis: It is usually referred to as Dong quay. This Chinese natural remedy extract contains a high concentration of furocoumarin, also known as psoralen. Psoralens are strong photosensitizers in the presence of UVA. Exposure to UVA, following psoralen ingestion, causes epidermal DNA cross-linking and, for this reason, a lower fee of epidermal DNA synthesis. Patients self-administer a type of psoralen–UVA (PUVA) remedy by ingesting dong quay, followed by receiving ultraviolet mild remedy or herbal sunlight. In Koo and Arain's (1998) study of sufferers with psoriasis, two-thirds of the sufferers were given complete alleviation from their disorder after oral remedy with this plant extract. Another herb utilised in treating psoriasis is hogweed (Heracleum sphondylium) , additionally consists of psoralen, but the efficacy and facet outcomes aren't available.

Conclusion

Psoriasis is a complex multifunctional inflammatory skin disease characterised by T cell activation, local vascular changes, abnormal keratinocyte proliferation, and neutrophil activation. Synthetic drugs used for treatment have side effects, and some synthetic drugs have been found to have psoriasis as a side effect. In this case, natural herbal remedies are an obvious alternative that is safe and as effective as synthetic drugs. This article highlights several plant sources based on traditional knowledge and reports from various researchers. Assay parameters, which are a key aspect of screening Chinese herbs, are also mentioned somewhere in the publication, and we hope they will be useful to researchers working in this field.