The debates on issues of global warming and reduction of greenhouse gases are common knowledge, and in this scenario, bioenergy gains strength and stands out as an efficient alternative. With the industrial development of the countries, an exponential increase in energy consumption will occur, and at the same time, energy demand will increase by an annual average of 1.6% by 2030 (Ghezloun et al., 2017). The importance of using biomass for power, heat, and fuel generation is increasing on a global scale. International and national policies, such as the European Action Plan for biomass and United Nations Conference on Climate Change (COP21) support the expansion of bioenergy, as they are considered climate-friendly compared to fossil fuels (Dressler et al., 2012). In this promising and challenging context, the production of biogas is returning to prominence and, consequently, has received numerous initiatives. Anaerobic digestion (AD), an attractive process for the management of liquid and solid waste that allows energy recovery through methane (CH4) and inside of AD, co-digestion have been highlighted since is an option to use poorly biodegradable substrates and providing and balancing macro and micronutrients for the AD process. sugarcane biorefineries in Brazil, vinasse is a residue from the production of 1G ethanol, commonly used for the production of biogas (Fuess et al., 2017). And to increase the energy recovery of vinasse, this research was to did co-digest the vinasse together with the filter cake (another residue from the production of 1G ethanol) and the deacetylation liquor (residue from the production of 2G ethanol (Brenelli et al., 2020)). Within the co-digestion of these residues in a continuous semi-fed reactor, it was possible to obtain biogas production which, when converted into electrical energy, exceeds by 400% the amount of energy produced only with vinasse.