Wound healing activity of leaves of Cassia tora Linn

The present study was aimed to evaluate the wound healing activity of extract of leaves of Cassia tora. Current methods used to treat wound include debridement, antibiotics, tissue graft, proteolytic enzymes and corticosteroids which posse’s major drawback and unwanted side effects. Therefore the development of potent wound healer drug with fewer side effects is necessary. Wound healing activity of methanolic extract of leaves of Cassia tora Linn. was studied by excision and incision wound models on albino mice. Significant increase in the percentage of excision wound contraction, tensile strength of incision wound and remarkable reduction in period of complete epithelization was observed in the extract treated animals as compared to control. Granulation tissue of methanolic extract treated animals was subjected to histopathological examination showed enhance collagen formation and complete epidermis and less infiltration monocytes as compared to control. The results of present study indicated that methanolic extract ointment of Cassia tora Linn. exhibited significant (p< 0.01) wound healing activity , when compared with the control.

Author(s): Vandana Janghel, Nilesh Gupta and Umesh K. Jain

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