Urinary Trypsinogen versus Serum Amylase in Early Diagnosis of Acute Pancreacities

Acute pancreatitis is a common cause of abdominal pain in the emergency department. 20% of acute pancreatitis attacks are severe, with about 10-25% of mortality rate in severe acute pancreatitis1,2,3. Early diagnosis of acute pancreatitis is required for adequate treatment and better prognosis1,3,4. Atypical presentation is so frequent in pancreatitis causing difficulty in diagnosis and distinguishing from other causes of abdominal pain4. Pathophysiology in acute pancreatitis include activation of pancreatic proenzymes1. Premature activation of trypsinogen is considered as a common feature in all cases of acute pancreatitis irrespective of the cause. All the proenzymes are excreted in urine causing high levels of urinary amylase and trypsinogen1

Author(s): Pradeep Balineni

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