Type 2 Diabetes Mellitus as A Risk Factor for Development of Hepatocellular Carcinoma: Case-Control Hospital Based Study

AIM: To study the relationships between Type 2 diabetes mellitus (DM2) and the risk of hepatocellular carcinoma (HCC).

METHODS: We studied the association between DM2 and HCC in a large case-control study that enrolled 255 Egyptian patients with HCC (71.4% males, mean age 62± 10.2 years) matched for age and sex and free from hepatocellular carcinoma 305 patients constituted the control group.

RESULTS: Prevalence of DM2 was significantly higher in HCC patients (29.1.2% vs 10.2.7%; OR = 3.35 95%CI: 1.31-3.29.).The highest prevalence of diabetes was found in patients with hepatitis C was 30% followed by hepatitis B infection 20%.

CONCLUSION: DM2 in our patients is associated with a 3-fold increase risk of HCC so that we encourage prompt screening for HCC in diabetic patients with cirrhosis.

Key words: type 2 diabetes ,hepatocellular carcinoma ,insulin resistance

Author(s): Ibrahim El Bayoumy

Abstract | Full-Text | PDF

Share This Article