The Potential Role of Sfrp5 in the Treatment of Obesity

Obesity is frequently defined as excess body weight for a given height, which has become a central issue for the global health concern. Secreted frizzled‐related protein 5 (SFRP5) is an anti‐inflammatory adipokine secreted by adipocytes, which has been regarded as a “good” a adipokine that could promotes good health. Researchers believed that SFRP5 could become the therapeutic target for the treatment of obesity, which takes effect through SFRP5/Wnt pathway. The purpose of this review is to summarize the effects of SFRP5, including being the signature of obesity, inhibiting adipogenesis, regulating triglyceride metabolism and alleviating inflammation, which is important for our increased understanding of the potential therapeutic role of SFRP5 in metabolic disease.

Author(s): Mengnan Lu, Huangtao Chen, Guo Li, Jingyu Wang and Chunyan Yin

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