Historically, opioid administration has permeated anesthetic education and practice. Mu receptor modulation quickly and effectively treats various pain syndromes, but at a price. We now know the short- and long-term consequences and side effects of narcotic utilization and abuse, and society is demanding better outcomes. Unfortunately, pain and pain syndromes persist. These include acute surgical pain, chronic regional pain syndrome, phantom limb pain, fibromyalgia, and many other chronic pain syndromes. However, we are in a renaissance of analgesia therapy and are realizing increased desires for improved treatments and outcomes.
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