The neuroprotective effect of glutamate receptors group II agonists in an animal model of birth asphyxia is connected with inhibition of caspase independent apoptosis

Problem statement: Hypoxic-ischemic encephalopathy is one of the leading causes of neonatal death and permanent neurological dysfunction worldwide. It has recently been shown that activation of mGluR2/3 before or after ischemic injury leads to neuroprotection, but the exact mechanism of this effect is unclear. Purpose: The purpose of this study is to investigate whether activation of group II glutamate receptor agonists (mGluR2/3) after hypoxia-ischemia can reduce brain damage and inhibit cell apoptosis. Method: We used an animal model of hypoxic-ischemia (HI) in 7-day-old pups. The animals received unilateral carotid artery ligation combined with hypoxia for 75 minutes under 7.4% oxygen

Author(s): Ewelina Bratek, A Ziembowicz and E Salinska

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