The Multidisciplinary Approach To The Patients With Antiphospholipid Syndrome

OBJECTIVES: In the last three and half decades, a variety of clinical
manifestations involving almost all organs and tissues (cardiac,
pulmonary, neurological, renal, cutaneous, hematologic, gastrointestinal,
ocular, skeletal and endocrinology), have been described
associated with antiphospholipid antibodies (aPL). AIM: The aim
of this study was to investigate multidisciplinary approach to the
patients with antiphospholipid syndrome (APS).
PATIENTS AND METHODS: Our study includes a total of 508
APS patients; 520 were PAPS patients (283 female and 177 male,
mean age 44.0±12.9), while 148 had APS associated with SLE (133
female and 15 male, mean age 47.7±14.8). The diagnosis of APS
was made by the presence of aPL and other diagnostic criteria.
RESULTS: In our cohort SAPS patients had significantly higher
prevalence of aCL IgG, aCL IgM and aß2GPI IgG. Thrombosis
was diagnosed in 46.5% patients.Pseudoinfective endocarditis was
observed in 12.8% secondary APS patients and 3.1% in primary
APS patients (p=0.004).Presence of ß2GPI IgG was significantly
related to stroke, and overall ß2GPI (IgG and IgM) positivity was
significantly related to TIA in SAPS patients. Valvular manifestations
were significantly related to TIA in both groups of patients
and were independent risk factors for TIA in PAPS (OR 3.790 CI
1.597-8.998 p=0.003: table 2).

Author(s): Ljudmila Stojanovich

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