The efficacy of aqueous methanolic extract of Murraya koenigi (L.) Spreng in alloxan induced diabetic albino rats

Murraya koenigi (L.) Spreng (Rutaceae), is an indigenous medicinally important herb of Indian origin, has been used for centuries in the Ayurvedic System of Medicine. The present investigation was carried out to evaluate the antidiabetic effect of solvent extract of leaf of M.koenigi (L.) in alloxan induced diabetic albino rats. The leaves, bark and the roots of the plant are used in indigenous medicine as tonic, stomachic, stimulant and carminative. An infusion of the roasted leaves is used to prevent vomiting. The present study throws light on the further understanding and bioactivity of M.koenigii (L.) Spreng. In comparison with the efficacy of other crude extracts, aqueous methanolic extract display promising activity and significantly decreased the elevated blood glucose level, cholesterol, LDL, triglycerides, phospholipids, VLDL in comparison with standard control (glibenclamide - a standard drug used to treat Diabetes mellitus).

Author(s): S. Venkatesan Jayakumar and S. M. Krishna Ganesh

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